Learning to learn by using nonequilibrium training protocols for adaptable materials.
Proc Natl Acad Sci U S A
; 120(27): e2219558120, 2023 Jul 04.
Article
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| MEDLINE
| ID: mdl-37364104
ABSTRACT
Evolution in time-varying environments naturally leads to adaptable biological systems that can easily switch functionalities. Advances in the synthesis of environmentally responsive materials therefore open up the possibility of creating a wide range of synthetic materials which can also be trained for adaptability. We consider high-dimensional inverse problems for materials where any particular functionality can be realized by numerous equivalent choices of design parameters. By periodically switching targets in a given design algorithm, we can teach a material to perform incompatible functionalities with minimal changes in design parameters. We exhibit this learning strategy for adaptability in two simulated settings elastic networks that are designed to switch deformation modes with minimal bond changes and heteropolymers whose folding pathway selections are controlled by a minimal set of monomer affinities. The resulting designs can reveal physical principles, such as nucleation-controlled folding, that enable such adaptability.
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MEDLINE
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En
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Proc Natl Acad Sci U S A
Año:
2023
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Article