Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance.
Oncoimmunology
; 12(1): 2224672, 2023.
Article
en En
| MEDLINE
| ID: mdl-37405191
ABSTRACT
In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM-1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Microbioma Gastrointestinal
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Oncoimmunology
Año:
2023
Tipo del documento:
Article
País de afiliación:
Francia