Pyroptosis and inflammationmediated endothelial dysfunction may act as key factors in the development of erectile dysfunction (Review).
Mol Med Rep
; 28(3)2023 Sep.
Article
en En
| MEDLINE
| ID: mdl-37449500
ABSTRACT
Erectile dysfunction (ED) is a prevalent disease that causes sexual dysfunction in males. Inflammationinduced endothelial dysfunction is a fundamental pathophysiological symptom of ED, which is impacted by cell death. Pyroptosis is a type of programmed cell death mediated by the inflammasome that was discovered in inflammatory disorders. The activation of nucleotidebinding oligomerization domainlike receptors, particularly downstream inflammatory factors, such as IL1ß and IL18, is indicative of caspasedependent pyroptosis. Although the underlying mechanisms of pyroptosis have been investigated in several disorders, the role of pyroptosis in ED remains to be fully elucidated. At present, studies on pyroptosis have focused on improving the understanding of ED pathogenesis and promoting the development of novel therapeutic options. The present review article aimed to discuss the literature surrounding the mechanisms underlying pyroptosis, and summarize the role of pyroptosis in the development and progression of inflammationmediated ED.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piroptosis
/
Disfunción Eréctil
Tipo de estudio:
Etiology_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Mol Med Rep
Año:
2023
Tipo del documento:
Article