Pyroptosis and inflammation­mediated endothelial dysfunction may act as key factors in the development of erectile dysfunction (Review).

ABSTRACT

Erectile dysfunction (ED) is a prevalent disease that causes sexual dysfunction in males. Inflammation­induced endothelial dysfunction is a fundamental pathophysiological symptom of ED, which is impacted by cell death. Pyroptosis is a type of programmed cell death mediated by the inflammasome that was discovered in inflammatory disorders. The activation of nucleotide­binding oligomerization domain­like receptors, particularly downstream inflammatory factors, such as IL­1ß and IL­18, is indicative of caspase­dependent pyroptosis. Although the underlying mechanisms of pyroptosis have been investigated in several disorders, the role of pyroptosis in ED remains to be fully elucidated. At present, studies on pyroptosis have focused on improving the understanding of ED pathogenesis and promoting the development of novel therapeutic options. The present review article aimed to discuss the literature surrounding the mechanisms underlying pyroptosis, and summarize the role of pyroptosis in the development and progression of inflammation­mediated ED.