Unraveling the roles of endoplasmic reticulum-associated degradation in metabolic disorders.
Front Endocrinol (Lausanne)
; 14: 1123769, 2023.
Article
en En
| MEDLINE
| ID: mdl-37455916
ABSTRACT
Misfolded proteins retained in the endoplasmic reticulum cause many human diseases. ER-associated degradation (ERAD) is one of the protein quality and quantity control system located at ER, which is responsible for translocating the misfolded proteins or properly folded but excess proteins out of the ER for proteasomal degradation. Recent studies have revealed that mice with ERAD deficiency in specific cell types exhibit impaired metabolism homeostasis and metabolic diseases. Here, we highlight the ERAD physiological functions in metabolic disorders in a substrate-dependent and cell type-specific manner.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Degradación Asociada con el Retículo Endoplásmico
/
Enfermedades Metabólicas
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Front Endocrinol (Lausanne)
Año:
2023
Tipo del documento:
Article
País de afiliación:
China