Resilient functioning is associated with altered structural brain network topology in adolescents exposed to childhood adversity.
Dev Psychopathol
; 35(5): 2253-2263, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-37493043
ABSTRACT
Childhood adversity is one of the strongest predictors of adolescent mental illness. Therefore, it is critical that the mechanisms that aid resilient functioning in individuals exposed to childhood adversity are better understood. Here, we examined whether resilient functioning was related to structural brain network topology. We quantified resilient functioning at the individual level as psychosocial functioning adjusted for the severity of childhood adversity in a large sample of adolescents (N = 2406, aged 14-24). Next, we examined nodal degree (the number of connections that brain regions have in a network) using brain-wide cortical thickness measures in a representative subset (N = 275) using a sliding window approach. We found that higher resilient functioning was associated with lower nodal degree of multiple regions including the dorsolateral prefrontal cortex, the medial prefrontal cortex, and the posterior superior temporal sulcus (z > 1.645). During adolescence, decreases in nodal degree are thought to reflect a normative developmental process that is part of the extensive remodeling of structural brain network topology. Prior findings in this sample showed that decreased nodal degree was associated with age, as such our findings of negative associations between nodal degree and resilient functioning may therefore potentially resemble a more mature structural network configuration in individuals with higher resilient functioning.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Resiliencia Psicológica
/
Experiencias Adversas de la Infancia
/
Trastornos Mentales
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Humans
Idioma:
En
Revista:
Dev Psychopathol
Asunto de la revista:
PSICOLOGIA
/
PSIQUIATRIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Reino Unido