Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats.
Br J Anaesth
; 131(3): 531-541, 2023 09.
Article
en En
| MEDLINE
| ID: mdl-37543435
ABSTRACT
BACKGROUND:
Sleep disorders can profoundly affect neurological function. We investigated changes in social and anxiety-related brain functional connectivity induced by sleep deprivation, and the potential therapeutic effects of the general anaesthetics propofol and sevoflurane in rats.METHODS:
Twelve-week-old male Sprague-Dawley rats were subjected to sleep deprivation for 20 h per day (from 1400 to 1000 the next day) for 4 consecutive weeks. They were free from sleep deprivation for the remaining 4 h during which they received propofol (40 mg kg-1 i.p.) or sevoflurane (2% for 2 h) per day or no treatment. These cohorts were instrumented for EEG/EMG recordings on days 2, 14, and 28. Different cohorts were used for open field and three-chambered social behavioural tests, functional MRI, nuclear magnetic resonance spectroscopy, and positron emission tomography imaging 48 h after 4 weeks of sleep deprivation.RESULTS:
Propofol protected against sleep deprivation-induced anxiety behaviours with more time (44.7 [8.9] s vs 24.2 [4.1] s for the sleep-deprivation controls; P<0.001) spent in the central area of the open field test and improved social preference index by 30% (all P<0.01). Compared with the sleep-deprived rats, propofol treatment enhanced overall functional connectivity by 74% (P<0.05) and overall glucose metabolism by 30% (P<0.01), and improved glutamate kinetics by 20% (P<0.05). In contrast, these effects were not found after sevoflurane treatment.CONCLUSIONS:
Unlike sevoflurane, propofol reduced sleep deprivation-induced social and anxiety-related behaviours. Propofol might be superior to sevoflurane for patients with sleep disorders who receive anaesthesia, which should be studied in clinical studies.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ansiedad
/
Privación de Sueño
/
Propofol
/
Anestésicos por Inhalación
/
Éteres Metílicos
Límite:
Animals
Idioma:
En
Revista:
Br J Anaesth
Año:
2023
Tipo del documento:
Article
País de afiliación:
China