The potential for citrate to reinforce epigenetic therapy by promoting apoptosis.

Icard, Philippe; Alifano, Marco; Simula, Luca

Icard, Philippe; Alifano, Marco; Simula, Luca.

Afiliación

Icard P; Normandie University, UNICAEN, INSERM U1086 Interdisciplinary Research Unit for Cancer Prevention and Treatment, Caen, France; Service de Chirurgie Thoracique, Hôpital Cochin, Hôpitaux Universitaires Paris Centre, APHP, Université Paris-Descartes, Paris, France. Electronic address: philippe.icard@aphp.fr.
Alifano M; Service de Chirurgie Thoracique, Hôpital Cochin, Hôpitaux Universitaires Paris Centre, APHP, Université Paris-Descartes, Paris, France; INSERM U1138, Integrative Cancer Immunology, University of Paris, 75006 Paris, France.
Simula L; Cochin Institute, INSERM U1016, CNRS UMR8104, University of Paris-Cité, Paris, 75014, France.

Trends Endocrinol Metab ; 34(10): 586-589, 2023 10.

Article en En | MEDLINE | ID: mdl-37550099

ABSTRACT

ABSTRACT

Epigenetic drugs induce ATP depletion, promoting a glycolysis-to-oxidative phosphorylation (OXPHOS) shift which sometimes favors tumor growth by promoting necroptosis over apoptosis. To restore effective apoptosis in tumors, we propose that the administration of citrate could inhibit ATP production, activate caspase-8 (a key necroptosis inhibitor), and downregulate key anti-apoptotic proteins (Bcl-xL and MCL1).

Asunto(s)

Ácido Cítrico; Neoplasias; Humanos; Ácido Cítrico/farmacología; Proteína bcl-X/genética; Proteína bcl-X/metabolismo; Proteína bcl-X/farmacología; Apoptosis/genética; Citratos/farmacología; Neoplasias/tratamiento farmacológico; Neoplasias/genética; Adenosina Trifosfato; Epigénesis Genética/genética

Palabras clave

Warburg effect; apoptosis; citrate; drug resistance; epigenetic drug; necroptosis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ácido Cítrico / Neoplasias Límite: Humans Idioma: En Revista: Trends Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2023 Tipo del documento: Article

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