[Induction of papilloma and carcinoma in the forestomach of mice by in vivo formation of N-3-methylbutyl-N-1-methylacetonylnitrosamine (MAMBNA)].

ABSTRACT

Forestomach papilloma and carcinoma, as well as liver lesion, were induced in mice by gavaging precursors of the new nitrosamine, MAMBNA (N-3-methylbutyl-N-1-methylacetonylnitrosamine) and NaNO2. The results were-similar to those in mice and rats fed on preformed MAMBNA compound. However, the induction of such tumors by in vivo formation of MAMBNA required longer time and much larger doses. Moreover, the lesions of epithelial hyperplasia in the urinary bladder, lymphoid tumor, intestinal carcinoma and interstitial-cell tumor of the testis also developed in some of the experimental animals. This may indicate that the intragastric synthesis of MAMBNA is less effective in the production of forestomach tumors in mice.