[Induction of papilloma and carcinoma in the forestomach of mice by in vivo formation of N-3-methylbutyl-N-1-methylacetonylnitrosamine (MAMBNA)].
Zhonghua Zhong Liu Za Zhi
; 8(4): 245-6, 1986 Jul.
Article
en Zh
| MEDLINE
| ID: mdl-3757735
ABSTRACT
Forestomach papilloma and carcinoma, as well as liver lesion, were induced in mice by gavaging precursors of the new nitrosamine, MAMBNA (N-3-methylbutyl-N-1-methylacetonylnitrosamine) and NaNO2. The results were-similar to those in mice and rats fed on preformed MAMBNA compound. However, the induction of such tumors by in vivo formation of MAMBNA required longer time and much larger doses. Moreover, the lesions of epithelial hyperplasia in the urinary bladder, lymphoid tumor, intestinal carcinoma and interstitial-cell tumor of the testis also developed in some of the experimental animals. This may indicate that the intragastric synthesis of MAMBNA is less effective in the production of forestomach tumors in mice.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Papiloma
/
Neoplasias Gástricas
/
Nitrosaminas
Límite:
Animals
Idioma:
Zh
Revista:
Zhonghua Zhong Liu Za Zhi
Año:
1986
Tipo del documento:
Article