A novel phosphorylation site involved in dissociating RAF kinase from the scaffolding protein 14-3-3 and disrupting RAF dimerization.

Yu, Alison; Nguyen, Duc Huy; Nguyen, Thomas Joseph; Wang, Zhihong

Yu, Alison; Nguyen, Duc Huy; Nguyen, Thomas Joseph; Wang, Zhihong.

Afiliación

Yu A; Department of Chemistry & Biochemistry, Rowan University, Glassboro, New Jersey, USA.
Nguyen DH; Department of Chemistry & Biochemistry, Rowan University, Glassboro, New Jersey, USA.
Nguyen TJ; Department of Chemistry & Biochemistry, Rowan University, Glassboro, New Jersey, USA.
Wang Z; Department of Chemistry & Biochemistry, Rowan University, Glassboro, New Jersey, USA. Electronic address: wangz@rowan.edu.

J Biol Chem ; 299(10): 105188, 2023 Oct.

Article en En | MEDLINE | ID: mdl-37625591

Palabras clave

14-3-3; ATP-competitive inhibitor; RAF kinase; cancer; dimerization; kinase signaling; paradoxical activation; phosphorylation; regulatory mechanism; scaffolding protein

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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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