Your browser doesn't support javascript.
loading
Transition-Metal-Free Base-Promoted Deaminative Coupling of Gramines with Aminomaleimides.
Gao, Qiwen; Luo, Liuting; Chen, Chen; Wen, Kangmei; Zhu, Zhibo; Tang, Xiaodong.
Afiliación
  • Gao Q; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1023 South Shatai Road, Baiyun District, Guangzhou 510515, China.
  • Luo L; Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 13# Shiliugang Road, Haizhu district, Guangzhou 510315, China.
  • Chen C; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1023 South Shatai Road, Baiyun District, Guangzhou 510515, China.
  • Wen K; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1023 South Shatai Road, Baiyun District, Guangzhou 510515, China.
  • Zhu Z; Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 13# Shiliugang Road, Haizhu district, Guangzhou 510315, China.
  • Tang X; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1023 South Shatai Road, Baiyun District, Guangzhou 510515, China.
J Org Chem ; 88(18): 13303-13314, 2023 Sep 15.
Article en En | MEDLINE | ID: mdl-37668535
The direct utilization of amines for C-C bond formation without prefunctionalization remains a significant challenge. Herein, we report the base-promoted deaminative coupling of gramines with aminomalaimides under redox-neutral conditions. In this operationally simple reaction, a series of indolmethyl-substituted aminomaleimides that emitted fluorescence were synthesized in good-to-excellent yields. Biological evaluation revealed that some products exhibited antiproliferative activity against human cancer cell lines.

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2023 Tipo del documento: Article País de afiliación: China