The Mediating Roles of Neurobiomarkers in the Relationship Between Education and Late-Life Cognition.
J Alzheimers Dis
; 95(4): 1405-1416, 2023.
Article
en En
| MEDLINE
| ID: mdl-37694365
ABSTRACT
BACKGROUND:
The mediating roles of neuropathologies and neurovascular damage in the relationship between early-life education and later-life cognitive function are unknown.OBJECTIVE:
To examine whether Alzheimer's and neurovascular biomarkers mediate the relationships between education and cognitive functions.METHODS:
Data were from 537 adults aged 55-94 in the Alzheimer's Disease Neuroimaging Initiative 3. We tested whether the relationships between education (continuous, years) and cognitive function (memory, executive functioning, and language composites) were mediated by neuroimaging biomarkers (hippocampal volumes, cortical gray matter volumes, meta-temporal tau PET standard uptake value ratio, and white matter hyperintensity volumes). Models were adjusted for age, race, sex/gender, cardiovascular history, body mass index, depression, and Apolipoprotein E-É4 status.RESULTS:
Hippocampal volumes and white matter hyperintensities partially mediated the relationships between education and cognitive function across all domains (6.43% to 15.72% mediated). The direct effects of education on each cognitive domain were strong and statistically significant.CONCLUSIONS:
Commonly measured neurobiomarkers only partially mediate the relationships between education and multi-domain cognitive function.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedad de Alzheimer
/
Disfunción Cognitiva
/
Sustancia Blanca
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos