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Coexistence of Amyotrophic Lateral Sclerosis and Alzheimer's Disease: Case Report and Review of the Literature.
Verde, Federico; Aiello, Edoardo Nicolò; Adobbati, Laura; Poletti, Barbara; Solca, Federica; Tiloca, Cinzia; Sangalli, Davide; Maranzano, Alessio; Muscio, Cristina; Ratti, Antonia; Zago, Stefano; Ticozzi, Nicola; Frisoni, Giovanni Battista; Silani, Vincenzo.
Afiliación
  • Verde F; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
  • Aiello EN; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milan, Italy.
  • Adobbati L; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
  • Poletti B; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
  • Solca F; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
  • Tiloca C; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.
  • Sangalli D; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
  • Maranzano A; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
  • Muscio C; Department of Neurology and Stroke Unit, Azienda Socio Sanitaria Territoriale Lecco, Lecco, Italy.
  • Ratti A; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
  • Zago S; Neurology-5 (Neuropathology) Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
  • Ticozzi N; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
  • Frisoni GB; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy.
  • Silani V; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
J Alzheimers Dis ; 95(4): 1383-1399, 2023.
Article en En | MEDLINE | ID: mdl-37694369
ABSTRACT
We describe a case of amyotrophic lateral sclerosis (ALS) associated with Alzheimer's disease (AD) and review the literature about the coexistence of the two entities, highlighting the following mean age at onset is 63.8 years, with slight female predominance; ALS tends to manifest after cognitive impairment and often begins in the bulbar region; average disease duration is 3 years; cognitive phenotype is mostly amnestic; the pattern of brain involvement is, in most cases, consistent with AD. Our case and the reviewed ones suggest that patients with ALS and dementia lacking unequivocal features of FTD should undergo additional examinations in order to recognize AD.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Demencia Frontotemporal / Enfermedad de Alzheimer / Disfunción Cognitiva / Esclerosis Amiotrófica Lateral Límite: Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia
Texto completo
Imprimir
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Demencia Frontotemporal / Enfermedad de Alzheimer / Disfunción Cognitiva / Esclerosis Amiotrófica Lateral Límite: Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia