Unveiling the Hidden Landscape of Arterial Diseases at Single-Cell Resolution.
Can J Cardiol
; 39(12): 1781-1794, 2023 12.
Article
en En
| MEDLINE
| ID: mdl-37716639
ABSTRACT
High-resolution single-cell technologies have shed light on the pathogenesis of cardiovascular diseases by enabling the discovery of novel cellular and transcriptomic signatures associated with various conditions, and uncovering new contributions of inflammatory processes, immunity, metabolic stress, and risk factors. We review the information obtained from studies using single-cell technologies in tissues with atherosclerosis and aortic aneurysms. Insights are provided on the biology of endothelial, smooth muscle, and immune cells in the arterial intima and media. In addition to cellular diversity, numerous examples of plasticity and phenotype switching are highlighted and presented in the context of normal cell functions.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Aterosclerosis
/
Músculo Liso Vascular
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Can J Cardiol
Asunto de la revista:
CARDIOLOGIA
Año:
2023
Tipo del documento:
Article