Lupenone attenuates thapsigargin-induced endoplasmic reticulum stress and apoptosis in pancreatic beta cells possibly through inhibition of protein tyrosine kinase 2 activity.

Song, Seung-Eun; Shin, Su-Kyung; Kim, Yong-Woon; Do, Young Rok; Lim, Ae Kyoung; Bae, Jae-Hoon; Jeong, Gil-Saeng; Im, Seung-Soon; Song, Dae-Kyu

Song, Seung-Eun; Shin, Su-Kyung; Kim, Yong-Woon; Do, Young Rok; Lim, Ae Kyoung; Bae, Jae-Hoon; Jeong, Gil-Saeng; Im, Seung-Soon; Song, Dae-Kyu.

Afiliación

Song SE; Department of Physiology & Obesity-mediated Disease Research Center, Keimyung University School of Medicine, Daegu, South Korea.
Shin SK; Department of Food Science and Nutrition, Kyungpook National University, Daegu, South Korea.
Kim YW; Department of Physiology, Yeungnam University School of Medicine, Daegu, South Korea.
Do YR; Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea.
Lim AK; Department of Physiology & Obesity-mediated Disease Research Center, Keimyung University School of Medicine, Daegu, South Korea.
Bae JH; Department of Physiology & Obesity-mediated Disease Research Center, Keimyung University School of Medicine, Daegu, South Korea.
Jeong GS; Keimyung University, College of Pharmacy, Daegu, South Korea.
Im SS; Department of Physiology & Obesity-mediated Disease Research Center, Keimyung University School of Medicine, Daegu, South Korea.
Song DK; Department of Physiology & Obesity-mediated Disease Research Center, Keimyung University School of Medicine, Daegu, South Korea. Electronic address: dksong@kmu.ac.kr.

Life Sci ; 332: 122107, 2023 Nov 01.

Article en En | MEDLINE | ID: mdl-37739164

Asunto(s)

Diabetes Mellitus; Células Secretoras de Insulina; Lupanos; Triterpenos; Animales; Ratones; Apoptosis; Calcio/metabolismo; Línea Celular; Diabetes Mellitus/metabolismo; Estrés del Retículo Endoplásmico; Quinasa 1 de Adhesión Focal/metabolismo; Quinasa 2 de Adhesión Focal/metabolismo; Glucosa/metabolismo; Células Secretoras de Insulina/metabolismo; Fosforilación; Tapsigargina/efectos adversos; Triterpenos/metabolismo; Tirosina/metabolismo; Lupanos/farmacología

Palabras clave

2-Aminoethoxydiphenyl borate (PubChem CID: 1598); 4-Phenylbutyric acid (PubChem CID: 4775); Apoptosis; Beta-cell; Cyclopiazonic acid (PubChem CID: 54695722); ER stress; KN-93 (PubChem CID: 5312122); Lupenone; Lupenone (PubChem CID: 92158); Protein tyrosine kinase 2; SP600125 (PubChem CID: 8515); Sodium orthovanadate (PubChem CID: 61671); Store-operated calcium entry; Streptozotocin (PubChem CID: 29327); Thapsigargin (PubChem CID: 446378); W-7 (PubChem CID: 124887)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Triterpenos / Diabetes Mellitus / Células Secretoras de Insulina / Lupanos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2023 Tipo del documento: Article País de afiliación: Corea del Sur

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