Upregulation of the cfiA carbapenemase gene in a Bacteroides fragilis strain by the novel integrative and conjugative element Tn7563.

Stubhaug, Tore Taksdal; Zecic, Nermin; Skaare, Dagfinn

Stubhaug, Tore Taksdal; Zecic, Nermin; Skaare, Dagfinn.

Afiliación

Stubhaug TT; Vestfold Hospital Trust, Department of Microbiology, Tønsberg, Norway; University of Oslo, Institute of Clinical Medicine, Oslo, Norway. Electronic address: torstu@siv.no.
Zecic N; Vestfold Hospital Trust, Department of Microbiology, Tønsberg, Norway.
Skaare D; Vestfold Hospital Trust, Department of Microbiology, Tønsberg, Norway.

Anaerobe ; 83: 102785, 2023 Oct.

Article en En | MEDLINE | ID: mdl-37743024

ABSTRACT

ABSTRACT

We describe Tn7563, a 31,844-bp integrative and conjugative element (ICE) carrying promoters upregulating the cfiA carbapenemase gene in Bacteroides fragilis strain Tbg-22. Excision and circularization of Tn7563 was demonstrated by PCR. Previously, only insertion sequences (IS) have been shown to carry mobile promoters for cfiA.

Asunto(s)

Infecciones Bacterianas; Infecciones por Bacteroides; Humanos; Bacteroides fragilis/genética; Regulación hacia Arriba; Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo; beta-Lactamasas/genética; beta-Lactamasas/metabolismo; Elementos Transponibles de ADN

Palabras clave

Bacteroides; Carbapenemase; Gene expression; Integrative and conjugative elements

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Infecciones por Bacteroides Límite: Humans Idioma: En Revista: Anaerobe Año: 2023 Tipo del documento: Article

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