Your browser doesn't support javascript.
loading
Catecholamines Promote Ovarian Cancer Progression through Secretion of CXC-Chemokines.
Kim, Hyun Jung; Chang, Ha Kyun; Lee, Yul Min; Heo, Kyun.
Afiliación
  • Kim HJ; Department of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
  • Chang HK; Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
  • Lee YM; Antibody Research Institute, Kookmin University, Seoul 02707, Republic of Korea.
  • Heo K; Department of Obstetrics and Gynecology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15355, Republic of Korea.
Int J Mol Sci ; 24(18)2023 Sep 14.
Article en En | MEDLINE | ID: mdl-37762405
Considerable evidence has accumulated in the last decade supporting the notion that chronic stress is closely related to the growth, metastasis, and angiogenesis of ovarian cancer. In this study, we analyzed the conditioned media in SKOV3 ovarian cancer cell lines treated with catecholamines to identify secreted proteins responding to chronic stress. Here, we observed that epinephrine and norepinephrine enhanced the secretion and mRNA expression of CXC-chemokines (CXCL1, 2, 3, and 8). Neutralizing antibodies to CXCL8 and CXCL8 receptor (CXCR2) inhibitors significantly reduced catecholamine-mediated invasion of SKOV3 cells. Finally, we found that the concentration of CXCL1 and CXCL8 in the plasma of ovarian cancer patients increased with stage progression. Taken together, these findings suggest that stress-related catecholamines may influence ovarian cancer progression through the secretion of CXC-chemokines.
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article