Neurobiomarker and body temperature responses to recreational marathon running.
J Sci Med Sport
; 26(11): 566-573, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-37777396
ABSTRACT
OBJECTIVES:
To assess how biomarkers indicating central nervous system insult (neurobiomarkers) vary in peripheral blood with exertional-heat stress from prolonged endurance exercise.DESIGN:
Observational study of changes in neuron specific enolase (NSE), S100 calcium-binding protein B (S100ß), Glial Fibrillary Acid Protein (GFAP) and Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) at Brighton Marathon 2022.METHODS:
In 38 marathoners with in-race core temperature (Tc) monitoring, exposure (High, Intermediate or Low) was classified by cumulative hyperthermia - calculated as area under curve of Timeâ¯×â¯Tcâ¯>â¯38⯰C - and also by running duration (finishing time). Blood was sampled for neurobiomarkers, cortisol and fluid-regulatory stress surrogates, including copeptin and creatinine (at rested baseline; within 30â¯min of finishing; and at 24â¯h).RESULTS:
Finishing in 236⯱â¯40â¯min, runners showed stable GFAP and UCH-L1 across the marathon and next-day. Significant (Pâ¯<â¯0.05) increases from baseline were shown post-marathon and at 24â¯h for S100ß (8.52 [3.65, 22.95] vs 39.0 [26.48, 52.33] vs 80.3 [49.1, 99.7] ng·L-1) and post-marathon only for NSE (3.73 [3.30, 4.32] vs 4.85 [4.45, 5.80] µg·L-1, Pâ¯<â¯0.0001). Whilst differential response to hyperthermia was observed for cortisol, copeptin and creatinine, neurobiomarker responses did not vary. Post-marathon, only NSE differed by exercise duration (High vs Low, 5.81⯱â¯1.77 vs. 4.69⯱â¯0.73 µg·L-1, adjusted Pâ¯=â¯0.0358).CONCLUSIONS:
Successful marathon performance did not associate with evidence for substantial neuronal insult. To account for variation in neurobiomarkers with prolonged endurance exercise, factors additional to hyperthermia, such as exercise duration and intensity, should be further investigated.Palabras clave
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Bases de datos:
MEDLINE
Asunto principal:
Carrera
/
Temperatura Corporal
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
J Sci Med Sport
Asunto de la revista:
MEDICINA ESPORTIVA
Año:
2023
Tipo del documento:
Article