Detection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie.
Vet Res
; 54(1): 89, 2023 Oct 04.
Article
en En
| MEDLINE
| ID: mdl-37794450
ABSTRACT
The emergence of bovine spongiform encephalopathy (BSE) prions from atypical scrapie has been recently observed upon experimental transmission to rodent and swine models. This study aimed to assess whether the inoculation of atypical scrapie could induce BSE-like disease in cattle. Four calves were intracerebrally challenged with atypical scrapie. Animals were euthanized without clinical signs of prion disease and tested negative for PrPSc accumulation by immunohistochemistry and western blotting. However, an emergence of BSE-like prion seeding activity was detected during in vitro propagation of brain samples from the inoculated animals. These findings suggest that atypical scrapie may represent a potential source of BSE infection in cattle.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Scrapie
/
Enfermedades de las Ovejas
/
Enfermedades de los Porcinos
/
Priones
/
Enfermedades de los Bovinos
/
Encefalopatía Espongiforme Bovina
/
Enfermedades por Prión
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Vet Res
Asunto de la revista:
MEDICINA VETERINARIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
España