Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics.
J Virol
; 97(10): e0101123, 2023 10 31.
Article
en En
| MEDLINE
| ID: mdl-37796123
ABSTRACT
IMPORTANCE Most studies investigating the characteristics of emerging SARS-CoV-2 variants have been focusing on mutations in the spike proteins that affect viral infectivity, fusogenicity, and pathogenicity. However, few studies have addressed how naturally occurring mutations in the non-spike regions of the SARS-CoV-2 genome impact virological properties. In this study, we proved that multiple SARS-CoV-2 Omicron BA.2 mutations, one in the spike protein and another downstream of the spike gene, orchestrally characterize this variant, shedding light on the importance of Omicron BA.2 mutations out of the spike protein.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Genoma Viral
/
Glicoproteína de la Espiga del Coronavirus
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SARS-CoV-2
/
Mutación
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Japón