Prevention and treatment of cisplatin-induced ototoxicity in adults: A systematic review.
Clin Otolaryngol
; 49(1): 1-15, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-37818931
ABSTRACT
OBJECTIVES:
Ototoxicity is a common disabling side effect of platinum-based chemotherapy. This study aimed to assess the evidence on the management of platinum-induced ototoxicity in adult cancer patients.METHODS:
Four databases were searched up to 1 November 2022. Original studies were included if they reported on a pharmacologic or non-pharmacologic intervention to prevent or treat platinum ototoxicity in adults. The articles' quality was assessed via two grading scales.RESULTS:
Nineteen randomised controlled trials and five quasi-experimental studies with 1673 patients were analysed. Eleven interventions were identified, nine pharmacological and two non-pharmacological. Six of the interventions (sodium thiosulphate, corticoids, sertraline, statins, multivitamins and D-methionine) showed mild benefits in preventing cisplatin-induced ototoxicity. Only one trial assessed corticoids as a potential treatment. Overall, only six trials were deemed with a low risk of bias. The majority of studies inadequately documented intervention-related adverse effects, thereby limiting safety conclusions.CONCLUSIONS:
Current interventions have mild benefits in preventing cisplatin-induced ototoxicity in adult cancer patients. Sodium thiosulphate is the most promising intervention as a preventive strategy. Rigorous, high-quality research is warranted, encompassing an evaluation of all potential symptoms and innovative treatment modalities.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ototoxicidad
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Pérdida Auditiva
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Neoplasias
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Antineoplásicos
Tipo de estudio:
Clinical_trials
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Systematic_reviews
Límite:
Adult
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Humans
Idioma:
En
Revista:
Clin Otolaryngol
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Colombia