Drosophila melanogaster as an organism model for studying cystic fibrosis and its major associated microbial infections.
Infect Immun
; 91(11): e0024023, 2023 Nov 16.
Article
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| MEDLINE
| ID: mdl-37847031
ABSTRACT
Cystic fibrosis (CF) is a human genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene that encodes a chloride channel. The most severe clinical manifestation is associated with chronic pulmonary infections by pathogenic and opportunistic microbes. Drosophila melanogaster has become the invertebrate model of choice for modeling microbial infections and studying the induced innate immune response. Here, we review its contribution to the understanding of infections with six major pathogens associated with CF (Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia, Mycobacterium abscessus, Streptococcus pneumoniae, and Aspergillus fumigatus) together with the perspectives opened by the recent availability of two CF models in this model organism.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Infecciones por Pseudomonas
/
Fibrosis Quística
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Infect Immun
Año:
2023
Tipo del documento:
Article
País de afiliación:
Francia