Fabrication of D-&#945;-tocopheryl polyethylene glycol 1000 succinates and human serum albumin conjugated chitosan nanoparticles of bosutinib for colon targeting application; in vitro-in vivo investigation.

Manthalkar, Laxmi; Bhattacharya, Sankha; Hatware, Ketan; Sreelaya, Putrevu; Shah, Disha; Jain, Arinjay; Phatak, Niraj

Fabrication of D-α-tocopheryl polyethylene glycol 1000 succinates and human serum albumin conjugated chitosan nanoparticles of bosutinib for colon targeting application; in vitro-in vivo investigation.

Manthalkar, Laxmi; Bhattacharya, Sankha; Hatware, Ketan; Sreelaya, Putrevu; Shah, Disha; Jain, Arinjay; Phatak, Niraj.

Afiliación

Manthalkar L; Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, India.
Bhattacharya S; Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, India. Electronic address: sankhabhatt@gmail.com.
Hatware K; Department of Pharmacology, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, India.
Sreelaya P; Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, India.
Shah D; Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, India.
Jain A; Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, India.
Phatak N; Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra 425405, India.

Int J Biol Macromol ; 253(Pt 7): 127531, 2023 Dec 31.

Article en En | MEDLINE | ID: mdl-37858658

Asunto(s)

Quitosano; Neoplasias Colorrectales; Nanopartículas; Ratas; Animales; Humanos; Masculino; Nanopartículas/química; Polietilenglicoles/química; Vitamina E/química; Succinatos/química; Tamaño de la Partícula; Portadores de Fármacos/química

Palabras clave

Bosutinib; Chitosan; Colorectal cancer; Cytotoxicity; D-α-tocopheryl polyethylene glycol 1000 (TPGS); Drug delivery; Human serum albumin; Targeted therapy

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Quitosano / Nanopartículas Límite: Animals / Humans / Male Idioma: En Revista: Int J Biol Macromol Año: 2023 Tipo del documento: Article País de afiliación: India

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