Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation.

Frese-Schaper, Manuela; Voll, Reinhard E; Frese, Steffen

Frese-Schaper, Manuela; Voll, Reinhard E; Frese, Steffen.

Afiliación

Frese-Schaper M; Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), a Leibniz Institute, Berlin, Germany.
Voll RE; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
Frese S; Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), a Leibniz Institute, Berlin, Germany. steffen.frese@email.de.

BMC Res Notes ; 16(1): 298, 2023 Oct 28.

Article en En | MEDLINE | ID: mdl-37898816

Asunto(s)

ADN-Topoisomerasas de Tipo I; Lupus Eritematoso Sistémico; Animales; Ratones; ADN-Topoisomerasas de Tipo I/genética; ADN-Topoisomerasas de Tipo I/metabolismo; Oligonucleótidos; Anticuerpos Antinucleares/metabolismo; ADN/genética

Palabras clave

Anti-dsDNA antibodies; Anti-dsDNA binding; Autoimmune disease; DNA relaxation; Systemic lupus erythematosus; Topoisomerase I

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ADN-Topoisomerasas de Tipo I / Lupus Eritematoso Sistémico Límite: Animals Idioma: En Revista: BMC Res Notes Año: 2023 Tipo del documento: Article País de afiliación: Alemania

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