Multi-scale characterisation of homologous recombination deficiency in breast cancer.

Jacobson, Daniel H; Pan, Shi; Fisher, Jasmin; Secrier, Maria

Jacobson, Daniel H; Pan, Shi; Fisher, Jasmin; Secrier, Maria.

Afiliación

Jacobson DH; UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, UK.
Pan S; UCL Cancer Institute, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
Fisher J; UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, UK.
Secrier M; UCL Cancer Institute, University College London, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.

Genome Med ; 15(1): 90, 2023 11 02.

Article en En | MEDLINE | ID: mdl-37919776

Asunto(s)

Antineoplásicos; Neoplasias de la Mama; Humanos; Femenino; Neoplasias de la Mama/genética; Neoplasias de la Mama/patología; Proteína BRCA1/genética; Inhibidores de Poli(ADP-Ribosa) Polimerasas/uso terapéutico; Funciones de Verosimilitud; Proteína BRCA2/genética; Recombinación Homóloga; Antineoplásicos/uso terapéutico; Microambiente Tumoral

Palabras clave

Breast cancer; Homologous recombination deficiency; Mutational signatures; PARP inhibition; Single cell; Transcriptional classifier; Tumour microenvironment

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Antineoplásicos Límite: Female / Humans Idioma: En Revista: Genome Med Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido

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