[Translated article] Sarcoid-like Reactions to Immune Checkpoint Inhibitors.
Actas Dermosifiliogr
; 115(1): T80-T83, 2024 Jan.
Article
en En, Es
| MEDLINE
| ID: mdl-37923080
ABSTRACT
Immune checkpoint inhibitors (ICIs) can cause immune-mediated cutaneous adverse events, including sarcoid-like reactions. The aim of this study was to retrospectively analyze clinical and histologic data from patients who developed cutaneous sarcoid-like reactions between 2019 and 2022 while under treatment with ICIs. We studied 7 patients (6 women and 1 man) with a median age of 65years. Median time to onset of symptoms was 4months. The most common presentation was papular sarcoidosis of the knees followed by subcutaneous sarcoidosis. Diagnosis was confirmed histologically in all cases, and no differences were observed relative to idiopathic sarcoidosis. Discontinuation of ICI therapy was required in just two patients. ICI-induced sarcoid-like reactions tend to be mild and generally do not require treatment discontinuation. Histologic confirmation is essential for distinguishing these reactions from tumor progression.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sarcoidosis
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Enfermedades de la Piel
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Neoplasias Cutáneas
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
/
Es
Revista:
Actas Dermosifiliogr
Año:
2024
Tipo del documento:
Article