Regulating Striated Muscle Contraction: Through Thick and Thin.
Annu Rev Physiol
; 86: 255-275, 2024 Feb 12.
Article
en En
| MEDLINE
| ID: mdl-37931167
ABSTRACT
Force generation in striated muscle is primarily controlled by structural changes in the actin-containing thin filaments triggered by an increase in intracellular calcium concentration. However, recent studies have elucidated a new class of regulatory mechanisms, based on the myosin-containing thick filament, that control the strength and speed of contraction by modulating the availability of myosin motors for the interaction with actin. This review summarizes the mechanisms of thin and thick filament activation that regulate the contractility of skeletal and cardiac muscle. A novel dual-filament paradigm of muscle regulation is emerging, in which the dynamics of force generation depends on the coordinated activation of thin and thick filaments. We highlight the interfilament signaling pathways based on titin and myosin-binding protein-C that couple thin and thick filament regulatory mechanisms. This dual-filament regulation mediates the length-dependent activation of cardiac muscle that underlies the control of the cardiac output in each heartbeat.
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Bases de datos:
MEDLINE
Asunto principal:
Actinas
/
Músculo Esquelético
Límite:
Humans
Idioma:
En
Revista:
Annu Rev Physiol
Año:
2024
Tipo del documento:
Article