Role of cytosolic and endoplasmic reticulum Ca2+ in pancreatic beta-cells: pros and cons.
Pflugers Arch
; 476(2): 151-161, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-37940681
ABSTRACT
Pancreatic beta cells utilize Ca2+ to secrete insulin in response to glucose. The glucose-dependent increase in cytosolic Ca2+ concentration ([Ca2+]C) activates a series of insulin secretory machinery in pancreatic beta cells. Therefore, the amount of insulin secreted in response to glucose is determined in a [Ca2+]C-dependent manner, at least within a moderate range. However, the demand for insulin secretion may surpass the capability of beta cells. Abnormal elevation of [Ca2+]C levels beyond the beta-cell endurance capacity can damage them by inducing endoplasmic reticulum (ER) stress and cell death programs such as apoptosis. Therefore, while Ca2+ is essential for the insulin secretory functions of beta cells, it could affect their survival at pathologically higher levels. Because an increase in beta-cell [Ca2+]C is inevitable under certain hazardous conditions, understanding the regulatory mechanism for [Ca2+]C is important. Therefore, this review discusses beta-cell function, survival, ER stress, and apoptosis associated with intracellular and ER Ca2+ homeostasis.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Células Secretoras de Insulina
Idioma:
En
Revista:
Pflugers Arch
Año:
2024
Tipo del documento:
Article
País de afiliación:
Corea del Sur