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A molecular chemodosimeter to probe "closed shell" ions in kidney cells.
Assel, Amine; Stanley, Meagan M; Mia, Rashid; Boulila, Besma; Cragg, Peter J; Owolabie, Iyanuoluwani; Hetrick, Meredith; Flynt, Alex; Wallace, Karl J; Ben Jannet, Hichem.
Afiliación
  • Assel A; Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia.
  • Stanley MM; Department of Chemistry and Biochemistry, School of Mathematics and Natural Science, The University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA. karl.wallace@usm.edu.
  • Mia R; Department of Chemistry and Biochemistry, School of Mathematics and Natural Science, The University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA. karl.wallace@usm.edu.
  • Boulila B; Department of Chemistry and Biochemistry, Stephen F Austin State University, P.O. Box 13006 SFA Station, Nacogdoches, TX 75962, USA.
  • Cragg PJ; Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia.
  • Owolabie I; School of Applied Chemical Sciences, University of Brighton, Brighton, BN2 4GJ, UK.
  • Hetrick M; Department of Cellular and Molecular Biology, The University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA.
  • Flynt A; Department of Cellular and Molecular Biology, The University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA.
  • Wallace KJ; Department of Cellular and Molecular Biology, The University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA.
  • Ben Jannet H; Department of Chemistry and Biochemistry, School of Mathematics and Natural Science, The University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA. karl.wallace@usm.edu.
Org Biomol Chem ; 21(47): 9379-9391, 2023 12 06.
Article en En | MEDLINE | ID: mdl-37975744
ABSTRACT
Two quinidine-functionalized coumarin molecular probes have been synthesized and have been found to bind metal cations (Cd2+, Co2+, Cu2+, Fe2+, Hg2+, Ni2+, and Zn2+) with high affinity in organic-aqueous media (DMSO-HEPES). The chemodosimeters coordinate with the Zn2+ ions in a two-to-one ratio (molecular probe Zn2+) with a log ß of 10.0 M-2. Upon the addition of the closed-shell metal ions studied, a fluorescence turn-on via an excimer formation is seen at 542 nm due to the quinaldine moiety adopting a syn arrangement when coordinated to the metal Zn2+ ions. Confocal microscopy monitored free Zn2+ ions in the Human Embryonic Kidney cell line HEK293 by coordinating with the chemodosimter.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Mercurio / Metales Límite: Humans Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Túnez
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Mercurio / Metales Límite: Humans Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Túnez