Round Bodies Detected by Treponema pallidum Immunohistochemical Stain in Two Cases of Cutaneous Syphilitic Gummata.
Am J Dermatopathol
; 46(1): 31-35, 2024 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-37982491
ABSTRACT
ABSTRACT Tertiary syphilis may present a diagnostic challenge due to negative nontreponemal serologies in up to 30% of cases and frequent lack of identifiable spirochetes on histopathology or other direct detection tests. We report 2 cases of round bodies staining with Treponema pallidum immunohistochemistry by light microscopy in biopsies from cutaneous syphilitic gummata. In 1 case, the finding was validated 3 times by 2 independent laboratories; in the other case, T. pallidum was detected by polymerase chain reaction in the biopsy sample. Spirochete round bodies have previously been reported in the setting of electron microscopy and fluorography, but to the best of our knowledge, have not been reported by light microscopy in a routine skin biopsy. Although the clinical implications are unclear, this may represent a helpful new paradigm for the diagnosis of tertiary syphilis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sífilis Cutánea
/
Sífilis
Límite:
Humans
Idioma:
En
Revista:
Am J Dermatopathol
/
Am. j. dermatopathol
/
American journal of dermatopathology
Año:
2024
Tipo del documento:
Article