Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation.
Curr Opin Pharmacol
; 73: 102415, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-38041933
ABSTRACT
Translating promising preclinical pain relief data for novel molecules from drug discovery to positive clinical trial outcomes is challenging. The angiotensin II type 2 (AT2) receptor is a clinically-validated target based upon positive proof-of-concept clinical trial data in patients with post-herpetic neuralgia. This trial was conducted because AT2 receptor antagonists evoked pain relief in rodent models of neuropathic pain. EMA401 was selected as the drug candidate based upon its suitable preclinical toxicity and safety profile and good pharmacokinetics. Herein, we provide an overview of the discovery, preclinical and clinical development of EMA401, for the alleviation of peripheral neuropathic pain.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Receptor de Angiotensina Tipo 2
/
Neuralgia
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Pharmacol
Asunto de la revista:
FARMACOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos