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Plant-derived Durvalumab variants show efficient PD-1/PD-L1 blockade and therapeutically favourable FcR binding.
Izadi, Shiva; Gumpelmair, Simon; Coelho, Pedro; Duarte, Henrique O; Gomes, Joana; Leitner, Judith; Kunnummel, Vinny; Mach, Lukas; Reis, Celso A; Steinberger, Peter; Castilho, Alexandra.
Afiliación
  • Izadi S; Department of Applied Genetics and Cell Biology, Institute for Plant Biotechnology and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
  • Gumpelmair S; Division of Immune Receptors and T Cell Activation, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  • Coelho P; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Duarte HO; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.
  • Gomes J; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Leitner J; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.
  • Kunnummel V; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Mach L; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.
  • Reis CA; Division of Immune Receptors and T Cell Activation, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  • Steinberger P; Department of Applied Genetics and Cell Biology, Institute for Plant Biotechnology and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
  • Castilho A; Department of Applied Genetics and Cell Biology, Institute for Plant Biotechnology and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Plant Biotechnol J ; 22(5): 1224-1237, 2024 May.
Article en En | MEDLINE | ID: mdl-38050338
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptor de Muerte Celular Programada 1 / Inhibidores de Puntos de Control Inmunológico / Anticuerpos Monoclonales Idioma: En Revista: Plant Biotechnol J Asunto de la revista: BIOTECNOLOGIA / BOTANICA Año: 2024 Tipo del documento: Article País de afiliación: Austria
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptor de Muerte Celular Programada 1 / Inhibidores de Puntos de Control Inmunológico / Anticuerpos Monoclonales Idioma: En Revista: Plant Biotechnol J Asunto de la revista: BIOTECNOLOGIA / BOTANICA Año: 2024 Tipo del documento: Article País de afiliación: Austria