Discovery of YSR734: A Covalent HDAC Inhibitor with Cellular Activity in Acute Myeloid Leukemia and Duchenne Muscular Dystrophy.

Raouf, Yasir S; Sedighi, Abootaleb; Geletu, Mulu; Frere, Geordon A; Allan, Rebecca G; Nawar, Nabanita; de Araujo, Elvin D; Gunning, Patrick T

Raouf, Yasir S; Sedighi, Abootaleb; Geletu, Mulu; Frere, Geordon A; Allan, Rebecca G; Nawar, Nabanita; de Araujo, Elvin D; Gunning, Patrick T.

Afiliación

Raouf YS; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada.
Sedighi A; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
Geletu M; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada.
Frere GA; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada.
Allan RG; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada.
Nawar N; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
de Araujo ED; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada.
Gunning PT; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

J Med Chem ; 66(24): 16658-16679, 2023 12 28.

Article en En | MEDLINE | ID: mdl-38060537

Asunto(s)

Leucemia Mieloide Aguda; Distrofia Muscular de Duchenne; Humanos; Inhibidores de Histona Desacetilasas/farmacología; Inhibidores de Histona Desacetilasas/uso terapéutico; Distrofia Muscular de Duchenne/tratamiento farmacológico; Isoformas de Proteínas/metabolismo; Histona Desacetilasas/metabolismo; Leucemia Mieloide Aguda/tratamiento farmacológico

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Distrofia Muscular de Duchenne Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Canadá

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