Visible-Light-Induced Photoredox 1,2-Dialkylation of Styrenes with α-Carbonyl Alkyl Bromides and Pyridin-1-ium Salts.
J Org Chem
; 89(1): 281-290, 2024 Jan 05.
Article
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| MEDLINE
| ID: mdl-38109762
ABSTRACT
A visible-light-driven photoredox dialkylation of styrenes with α-carbonyl alkyl bromides and pyridin-1-ium salts for the synthesis of polysubstituted 1,4-dihydropyridines is reported. This reaction enables the formation of two new C(sp3)-C(sp3) bonds in a single reaction step and provides a strategy that employs pyridin-1-ium salts as the functionalized alkylating reagents via dearomatization to directly trap the resulting alkyl radicals from radical addition of alkenes and then terminate the alkene dialkylation.
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Bases de datos:
MEDLINE
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En
Revista:
J Org Chem
Año:
2024
Tipo del documento:
Article
País de afiliación:
China