Clinical and immunopathological characteristics of autoimmune blistering skin diseases.
Acta Dermatovenerol Alp Pannonica Adriat
; 32(4): 141-149, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-38126096
ABSTRACT
Autoimmune blistering skin diseases (AIBDs) encompass several heterogeneous conditions clinically characterized by blisters and erosions on the skin and mucous membranes and are immunopathologically characterized by autoantibodies against structural proteins of the skin. Those proteins are responsible for the intercellular contact between epidermal keratinocytes and adhesion of the basal keratinocytes to the dermis. Therefore, AIBDs are divided into two main groups intraepidermal (the pemphigus group) and subepidermal (the pemphigoid) groups. The diagnostic methods for AIBDs have made tremendous progress in the last 2 decades due to the availability of standardized serological assays that allow precise diagnosis in most patients. If left untreated, these diseases are potentially life-threatening due to superinfections and loss of body fluids, and in some severe cases due to restricted food intake. Based on the available literature, this paper provides an overview of the clinical and immunopathological characteristics of the most common AIBDs.
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Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Penfigoide Ampolloso
/
Pénfigo
Límite:
Humans
Idioma:
En
Revista:
Acta Dermatovenerol Alp Pannonica Adriat
Asunto de la revista:
DERMATOLOGIA
/
DOENCAS SEXUALMENTE TRANSMISSIVEIS
Año:
2023
Tipo del documento:
Article