Grb7 knockout mice develop normally but litters born to knockout females fail to thrive.
Dev Dyn
; 253(7): 677-689, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38140940
ABSTRACT
BACKGROUND:
Growth factor receptor-bound 7 (Grb7) is an adaptor protein involved in signal transduction downstream of multiple receptor tyrosine kinases, including ERBB, FGFR, and PDGFR pathways. Experimental studies have implicated Grb7 in regulating cell proliferation, survival, migration, and invasion through its large repertoire of protein-protein interactions.RESULTS:
Here, we describe the generation and characterization of a Grb7 knockout mouse. These mice are viable and fertile. A lacZ knock-in reporter was used to visualize Grb7 promoter activity patterns in adult tissues, indicating widespread Grb7 expression in glandular epithelium, the central nervous system, and other tissues. The sole defect observed in these animals was a failure of Grb7 knockout females to successfully raise pups to weaning age, a phenotype that was independent of both paternal and pup genotypes.CONCLUSIONS:
These data suggest a regulatory role for Grb7 in mammary lactational physiology.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ratones Noqueados
/
Proteína Adaptadora GRB7
Límite:
Animals
Idioma:
En
Revista:
Dev Dyn
Asunto de la revista:
ANATOMIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos