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Longitudinal evaluation of major salivary gland functioning in Sjögren's disease patients in a prospective standard-of-care cohort.
Sluijpers, Niels R F; Delli, Konstantina; De Wolff, Liseth; Stel, Alja J; Spijkervet, Fred K L; Kroese, Frans G M; Bootsma, Hendrika; Arends, Suzanne; Vissink, Arjan.
Afiliación
  • Sluijpers NRF; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, The Netherlands. n.r.f.sluijpers@umcg.nl.
  • Delli K; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
  • De Wolff L; Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Stel AJ; Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Spijkervet FKL; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Kroese FGM; Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Bootsma H; Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Arends S; Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Vissink A; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
Clin Exp Rheumatol ; 41(12): 2474-2483, 2023 Dec.
Article en En | MEDLINE | ID: mdl-38149509
ABSTRACT

OBJECTIVES:

To evaluate changes in major salivary gland functioning over time using salivary gland ultrasonography (SGUS), salivary flow measurements (sialometry), and patient-reported outcome measures (PROMs) in patients diagnosed with primary Sjögren's disease (SjD).

METHODS:

Consecutive outpatients from the ongoing prospective REgistry of Sjögren Syndrome LongiTudinal (RESULT) cohort, all fulfilling the ACR-EULAR classification criteria for SjD, were included. SGUS images assessed with the Hocevar and OMERACT scoring system, unstimulated and stimulated whole saliva (UWS/SWS), unstimulated and stimulated submandibular/sublingual saliva (uSMSLS/sSMSLS) and parotid saliva, EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) general dryness, oral dryness, and Xerostomia Inventory were assessed at baseline (BL), 2-year (Y2) and 5-year (Y5) follow-up.

RESULTS:

In total, BL and Y2 data were available for 253 patients and 75 patients had already reached Y5. At group level, SGUS Hocevar (i.e., mean±SD 22±10 at BL, 22±10 at Y2 and 23±10 at Y5), OMERACT scores, UWS, SWS and PROMs remained stable over time (all p>0.05). Slightly decreased uSMSLS (p=0.025) and sSMSLS (p=0.004) were observed at Y5. At individual patient level, a similar proportion showed an increase or decrease of ≥25% for Hocevar, UWS and SWS. At baseline, poor associations were observed between SGUS and PROMs and fair associations between sialometry and PROMs. Over time, changes in objective assessments did not correlate with changes in PROMs.

CONCLUSIONS:

Overall, major salivary gland functioning assessed with SGUS, sialometry and PROMs did not change significantly up to 5 years of follow-up in a standard-of-care cohort of SjD patients from daily clinical practice.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Xerostomía / Síndrome de Sjögren Límite: Humans Idioma: En Revista: Clin Exp Rheumatol Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Xerostomía / Síndrome de Sjögren Límite: Humans Idioma: En Revista: Clin Exp Rheumatol Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos