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Photochemical Difluoromethylation of Quinoxalin-2(1H)-ones with Difluoroacetic Anhydride and Pyridine N-Oxide.
Zhang, Ying; Liu, Yu; Zhang, Yi; Zhu, Yaqing; Zhou, Ningning; Zhao, Xia; Lu, Kui.
Afiliación
  • Zhang Y; China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, TianJin University of Science &Technology, TianJin 300457, China.
  • Liu Y; China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, TianJin University of Science &Technology, TianJin 300457, China.
  • Zhang Y; China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, TianJin University of Science &Technology, TianJin 300457, China.
  • Zhu Y; China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, TianJin University of Science &Technology, TianJin 300457, China.
  • Zhou N; China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, TianJin University of Science &Technology, TianJin 300457, China.
  • Zhao X; College of Chemistry, TianJin Key Laboratory of Structure and Performance for Functional Molecules, TianJin Normal University, TianJin 300387, China.
  • Lu K; China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, TianJin University of Science &Technology, TianJin 300457, China.
J Org Chem ; 89(2): 1199-1208, 2024 Jan 19.
Article en En | MEDLINE | ID: mdl-38154054
ABSTRACT
A novel photochemical difluoromethylation of quinoxalin-2(1H)-ones under catalyst-free conditions was achieved with difluoroacetic anhydride and pyridine N-oxide. The green and mild reaction conditions as well as readily attainable difluoroacetic anhydride provide a useful protocol to prepare C3-difluoromethylated quinoxalin-2(1H)-ones.

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2024 Tipo del documento: Article País de afiliación: China