Long-term carriage and evolution of VREfmLong-term carriage and evolution of vancomycin-resistant Enterococcus faecium: a genomic study on consecutive isolates.
JAC Antimicrob Resist
; 6(1): dlad153, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38161962
ABSTRACT
Objectives:
To determine if vancomycin-resistant Enterococcus faecium (VREfm) carriers carry the same VREfm clone after a minimum follow-up of 365â days. For those carrying the same clone, we investigated the genomic evolution per year per genome.Methods:
We used WGS results to assign VREfm clones to each isolate and determine clone shifts. Finally, we calculated distance in core-genome MLST alleles, and the number of SNPs between consecutive VREfm isolates from patients carrying the same VREfm clone.Results:
In total, 44.2% of patients carried the same VREfm clone, and the genomic evolution was 1.8 alleles and 2.6 SNPs per genome per year.Conclusions:
In our population of long-term carriers, we calculated a molecular clock of 2.6 SNPs.
Texto completo:
1
Bases de datos:
MEDLINE
Idioma:
En
Revista:
JAC Antimicrob Resist
Año:
2024
Tipo del documento:
Article
País de afiliación:
Dinamarca