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Mechanochemical coupling of MGF mediates periodontal regeneration.
Zhao, Ying; Zhang, Songbai; Cheng, Bo; Feng, Fan; Zhu, Yue; Liu, Yanli; Wang, Junjun; Zou, Dehui; Ma, Heng; Xu, Feng; Zhang, Min.
Afiliación
  • Zhao Y; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency School of Stomatology, Fourth Military Medical Universit
  • Zhang S; Department of Anesthesiology and Perioperative Medicine Xi'an People's Hospital (Xi'an Fourth Hospital), Northwest University Xi'an People's Republic of China.
  • Cheng B; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency School of Stomatology, Fourth Military Medical Universit
  • Feng F; The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology, Xi'an Jiaotong University Xi'an People's Republic of China.
  • Zhu Y; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University Xi'an People's Republic of China.
  • Liu Y; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency School of Stomatology, Fourth Military Medical Universit
  • Wang J; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency School of Stomatology, Fourth Military Medical Universit
  • Zou D; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency School of Stomatology, Fourth Military Medical Universit
  • Ma H; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency School of Stomatology, Fourth Military Medical Universit
  • Xu F; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency School of Stomatology, Fourth Military Medical Universit
  • Zhang M; Department of Physiology & Department of Pathophysiology School of Basic Medical Sciences, Fourth Military Medical University Xi'an People's Republic of China.
Bioeng Transl Med ; 9(1): e10603, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38193124
ABSTRACT
Clinical evidence shows that the mechanical stimulation obtained from occlusion could enhance periodontal ligament (PDL) remodeling. Mechano-growth factor (MGF) is a growth factor produced specifically following mechanical stimulus Here, we aim to investigate the mechanical enhancement potential and mechanism of the MGF in PDL regeneration. In vivo study found that MGF produced from the PDL under occlusion force could strongly enhance PDL remodeling. In vitro experiments and mathematical modeling further confirmed the mechanical enhancement effect of MGF for PDLSC differentiation toward fibroblasts. A mechanochemical coupling effect of MGF mediated the enhancement of mechanical effect, which was modulated by Fyn-FAK kinases signaling and subsequent MAPK pathway. Finally, enhanced PDL regeneration under the mechanochemical coupling of MGF and occlusal force was verified in vivo. There exists an additive mechanical effect of MGF mediated by Fyn-FAK crosstalk and subsequent ERK1/2 and p38 phosphorylation, which could be developed as an MGF-centered adjuvant treatment to optimize PDL remodeling, especially for patients with weakened bite force or destroyed periodontium.
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioeng Transl Med Año: 2024 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioeng Transl Med Año: 2024 Tipo del documento: Article