Dual Nickel/Photoredox-Catalyzed Asymmetric Carbamoylation of Benzylic C(sp3 )-H Bonds.
Angew Chem Int Ed Engl
; 63(12): e202313717, 2024 Mar 18.
Article
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| MEDLINE
| ID: mdl-38214382
ABSTRACT
Radical-mediated Hydrogen Atom Abstraction of Csp3 -H bonds has become a powerful tool for the asymmetric functionalization of organic feedstocks. Here, we present an asymmetric synthesis of α-aryl amides via carbamoylation of alkylarenes with isocyanates as electrophiles. The synergistic combination of a photoredox and a chiral nickel-catalyst, enables the use of readily available and neutral reagents under mild reaction conditions and provides straightforward access to pharmacologically relevant motifs in enantiomerically pure form.
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MEDLINE
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En
Revista:
Angew Chem Int Ed Engl
Año:
2024
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Article
País de afiliación:
Suiza