Introducing the Dynamic Well-Stirred Model for Predicting Hepatic Clearance and Extraction Ratio.

Yan, Zhengyin; Ma, Li; Carione, Pasquale; Huang, Julie; Hwang, Nicky; Kenny, Jane R; Hop, Cornelis E C A

Yan, Zhengyin; Ma, Li; Carione, Pasquale; Huang, Julie; Hwang, Nicky; Kenny, Jane R; Hop, Cornelis E C A.

Afiliación

Yan Z; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA, 94080, USA. Electronic address: yanz7@gene.com.
Ma L; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA, 94080, USA.
Carione P; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA, 94080, USA.
Huang J; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA, 94080, USA.
Hwang N; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA, 94080, USA.
Kenny JR; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA, 94080, USA.
Hop CECA; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA, 94080, USA.

J Pharm Sci ; 113(4): 1094-1112, 2024 04.

Article en En | MEDLINE | ID: mdl-38220087

Asunto(s)

Midazolam; Modelos Biológicos; Humanos; Midazolam/metabolismo; Hígado/metabolismo; Unión Proteica; Albúminas/metabolismo; Verapamilo; Tasa de Depuración Metabólica; Preparaciones Farmacéuticas/metabolismo; Hepatocitos/metabolismo

Palabras clave

Clearance prediction; Dynamic free fraction; Dynamic well-stirred model; In vitro in vivo extrapolation; Well-stirred model

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Midazolam / Modelos Biológicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Pharm Sci Año: 2024 Tipo del documento: Article

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