A review of structural modification and biological activities of oleanolic acid.
Chin J Nat Med
; 22(1): 15-30, 2024 Jan.
Article
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| MEDLINE
| ID: mdl-38278556
ABSTRACT
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits a broad spectrum of biological activities, including antitumor, antiviral, antibacterial, anti-inflammatory, hepatoprotective, hypoglycemic, and hypolipidemic effects. Since its initial isolation and identification, numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives. Despite this, there has been a dearth of comprehensive reviews in the past two decades, leading to challenges in subsequent research on OA. Based on the main biological activities of OA, this paper comprehensively summarized the modification strategies and structure-activity relationships (SARs) of OA and its derivatives to provide valuable reference for future investigations into OA.
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Bases de datos:
MEDLINE
Asunto principal:
Ácido Oleanólico
/
Triterpenos
Idioma:
En
Revista:
Chin J Nat Med
Año:
2024
Tipo del documento:
Article