Association of Assisted Reproductive Technology and Stroke During Hospitalization for Delivery in the United States.
Stroke
; 55(4): 999-1005, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38299332
ABSTRACT
INTRODUCTION:
Infertility treatment with assisted reproductive technologies (ARTs) has been associated with adverse vascular events in some but not all previous studies. Endothelial damage, prothrombotic factor release, and a higher prevalence of cardiovascular risk factors in those receiving ART have been invoked to explain this association. We sought to explore the relationship between ART and stroke risk using population-level data.METHODS:
We conducted a retrospective cohort study using data from the National Inpatient Sample registry from 2015 to 2020, including all delivery hospitalizations for patients aged 15 to 55 years. The study exposure was use of ART. The primary end point was any stroke defined as ischemic stroke, subarachnoid hemorrhage, intracerebral hemorrhage, or cerebral venous thrombosis during index delivery hospitalization. Individual stroke subtypes (ischemic stroke, subarachnoid hemorrhage, intracerebral hemorrhage, and cerebral venous thrombosis) were evaluated as secondary end points. Standard International Classification of Diseases, Tenth Revision, Clinical Modification algorithms were used to define study exposure, comorbidities, and prespecified end points. In addition to reporting population-level estimates, propensity score adjustment by inverse probability weighting was used to mimic the effects of randomization by balancing baseline clinical characteristics associated with stroke between ART and non-ART users.RESULTS:
Among 19â 123â 125 delivery hospitalizations identified, patients with prior ART (n=202â 815, 1.1%) experienced significantly higher rates of any stroke (27.1/100â 000 versus 9.1/100â 000), ischemic stroke (9.9/100â 000 versus 3.3/100â 000), subarachnoid hemorrhage (7.4/100â 000 versus 1.6/100â 000), intracerebral hemorrhage (7.4/100â 000 versus 2.0/100â 000), and cerebral venous thrombosis (7.4/100â 000 versus 2.7/100â 000) in comparison to non-ART users (all P<0.001 for all unadjusted comparisons). Following inverse probability weighting analysis, ART was associated with increased odds of any stroke (adjusted odds ratios, 2.14 (95% CI, 2.02-2.26); P<0.001).CONCLUSIONS:
Using population-level data among patients hospitalized for delivery in the United States, we found an association between ART and stroke after adjustment for measured confounders.Palabras clave
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Bases de datos:
MEDLINE
Asunto principal:
Hemorragia Subaracnoidea
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Trombosis de la Vena
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Accidente Cerebrovascular
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Accidente Cerebrovascular Isquémico
Tipo de estudio:
Clinical_trials
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Stroke
Año:
2024
Tipo del documento:
Article