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Impact of multiscale surface topography characteristics on Candida albicans biofilm formation: From cell repellence to fungicidal activity.
Le, Phuc H; Linklater, Denver P; Medina, Arturo Aburto; MacLaughlin, Shane; Crawford, Russell J; Ivanova, Elena P.
Afiliación
  • Le PH; School of Science, STEM College, RMIT University, Melbourne, VIC 3000, Australia; ARC Research Hub for Australian Steel Manufacturing, Melbourne, VIC 3001, Australia.
  • Linklater DP; School of Science, STEM College, RMIT University, Melbourne, VIC 3000, Australia; ARC Research Hub for Australian Steel Manufacturing, Melbourne, VIC 3001, Australia; Department of Biomedical Engineering, The Graeme Clark Institute, University of Melbourne, Parkville, VIC 3010, Australia.
  • Medina AA; School of Science, STEM College, RMIT University, Melbourne, VIC 3000, Australia.
  • MacLaughlin S; ARC Research Hub for Australian Steel Manufacturing, Melbourne, VIC 3001, Australia; BlueScope Steel Research, Port Kembla, NSW 2505, Australia.
  • Crawford RJ; School of Science, STEM College, RMIT University, Melbourne, VIC 3000, Australia.
  • Ivanova EP; School of Science, STEM College, RMIT University, Melbourne, VIC 3000, Australia; ARC Research Hub for Australian Steel Manufacturing, Melbourne, VIC 3001, Australia. Electronic address: elena.ivanova@rmit.edu.au.
Acta Biomater ; 177: 20-36, 2024 03 15.
Article en En | MEDLINE | ID: mdl-38342192
ABSTRACT
While there has been significant research conducted on bacterial colonization on implant materials, with a focus on developing surface modifications to prevent the formation of bacterial biofilms, the study of Candida albicans biofilms on implantable materials is still in its infancy, despite its growing relevance in implant-associated infections. C. albicans fungal infections represent a significant clinical concern due to their severity and associated high fatality rate. Pathogenic yeasts account for an increasing proportion of implant-associated infections, since Candida spp. readily form biofilms on medical and dental device surfaces. In addition, these biofilms are highly antifungal-resistant, making it crucial to explore alternative solutions for the prevention of Candida implant-associated infections. One promising approach is to modify the surface properties of the implant, such as the wettability and topography of these substrata, to prevent the initial Candida attachment to the surface. This review summarizes recent research on the effects of surface wettability, roughness, and architecture on Candida spp. attachment to implantable materials. The nanofabrication of material surfaces are highlighted as a potential method for the prevention of Candida spp. attachment and biofilm formation on medical implant materials. Understanding the mechanisms by which Candida spp. attach to surfaces will allow such surfaces to be designed such that the incidence and severity of Candida infections in patients can be significantly reduced. Most importantly, this approach could also substantially reduce the need to use antifungals for the prevention and treatment of these infections, thereby playing a crucial role in minimizing the possibility contributing to instances of antimicrobial resistance. STATEMENT OF

SIGNIFICANCE:

In this review we provide a systematic analysis of the role that surface characteristics, such as wettability, roughness, topography and architecture, play on the extent of C. albicans cells attachment that will occur on biomaterial surfaces. We show that exploiting bioinspired surfaces could significantly contribute to the prevention of antimicrobial resistance to antifungal and chemical-based preventive measures. By reducing the attachment and growth of C. albicans cells using surface structure approaches, we can decrease the need for antifungals, which are conventionally used to treat such infections.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Candida albicans / Antifúngicos Límite: Humans Idioma: En Revista: Acta Biomater Año: 2024 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Candida albicans / Antifúngicos Límite: Humans Idioma: En Revista: Acta Biomater Año: 2024 Tipo del documento: Article País de afiliación: Australia