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Prognostic impact of histological discordance between transurethral resection and radical cystectomy.
Matsuda, Ayumu; Taoka, Rikiya; Miki, Jun; Saito, Ryoichi; Fukuokaya, Wataru; Hatakeyama, Shingo; Kawahara, Takashi; Fujii, Yoichi; Kato, Minoru; Sazuka, Tomokazu; Sano, Takeshi; Urabe, Fumihiko; Kashima, Soki; Naito, Hirohito; Murakami, Yoji; Miyake, Makito; Daizumoto, Kei; Matsushita, Yuto; Hayashi, Takuji; Inokuchi, Junichi; Sugino, Yusuke; Shiga, Kenichiro; Yamaguchi, Noriya; Iio, Hiroyuki; Yasue, Keiji; Abe, Takashige; Nakanishi, Shotaro; Matsumura, Masafumi; Fujii, Masato; Nishihara, Kiyoaki; Matsumoto, Hiroaki; Tatarano, Shuichi; Wada, Koichiro; Sekito, Sho; Maruyama, Ryo; Nishiyama, Naotaka; Nishiyama, Hiroyuki; Kitamura, Hiroshi; Matsui, Yoshiyuki.
Afiliación
  • Matsuda A; Department of Urology, National Cancer Center Hospital, Tokyo, Japan.
  • Taoka R; Department of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Miki J; Department of Urology, Jikei University Kashiwa Hospital, Chiba, Japan.
  • Saito R; Department of Urology, The Jikei University School of Medicine, Japan.
  • Fukuokaya W; Department of Urology and Andrology, Kansai Medical University, Osaka, Japan.
  • Hatakeyama S; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Kawahara T; Department of Urology, Jikei University Kashiwa Hospital, Chiba, Japan.
  • Fujii Y; Department of Urology, The Jikei University School of Medicine, Japan.
  • Kato M; Department of Urology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
  • Sazuka T; Department of Urology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
  • Sano T; Department of Urology, Graduate School of Medicine, The University of Tokyo, Japan.
  • Urabe F; Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
  • Kashima S; Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Naito H; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Murakami Y; Department of Urology, Jikei University Kashiwa Hospital, Chiba, Japan.
  • Miyake M; Department of Urology, Jikei University Hospital, Tokyo, Japan.
  • Daizumoto K; Department of Urology, Akita University Graduate School of Medicine, Akita, Japan.
  • Matsushita Y; Department of Urology, Kurashiki Central Hospital, Okayama, Japan.
  • Hayashi T; Department of Urology, Graduate School of Life Science, Kumamoto University, Kumamoto, Japan.
  • Inokuchi J; Department of Urology, Nara Medical University, Nara, Japan.
  • Sugino Y; Department of Urology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
  • Shiga K; Department of Urology, Hamamatsu University School of Medicine, Shizuoka, Japan.
  • Yamaguchi N; Department of Urology, Osaka International Cancer Institute, Osaka, Japan.
  • Iio H; Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Yasue K; Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Mie, Japan.
  • Abe T; Department of Urology, Harasanshin General Hospital, Fukuoka, Japan.
  • Nakanishi S; Department of Urology, Tottori University Faculty of Medicine, Tottori, Japan.
  • Matsumura M; Department of Urology, Hyogo College of Medicine, Hyogo, Japan.
  • Fujii M; Department of Urology, Jikei University Katsushika Medical Center, Tokyo, Japan.
  • Nishihara K; Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
  • Matsumoto H; Department of Urology, Graduate School of Medicine, University of Ryukyus, Okinawa, Japan.
  • Tatarano S; Department of Urology, National Hospital Organization Shikoku Cancer Center, Ehime, Japan.
  • Wada K; Department of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
  • Sekito S; Department of Urology, Kurume University School of Medicine, Fukuoka, Japan.
  • Maruyama R; Department of Urology Graduate School of Medicine Yamaguchi University, Yamaguchi, Japan.
  • Nishiyama N; Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  • Nishiyama H; Department of Urology, Shimane University Faculty of Medicine, Shimane, Japan.
  • Kitamura H; Department of Urology, Aichi Cancer Center Hospital, Aichi, Japan.
  • Matsui Y; Department of Urology, Niigata University Graduate School of Medicine, Niigata, Japan.
BJU Int ; 134(2): 207-218, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38344879
ABSTRACT

OBJECTIVE:

To analyse the impact of histological discordance of subtypes (subtypes or divergent differentiation [DD]) in specimens from transurethral resection (TUR) and radical cystectomy (RC) on the outcome of the patients with bladder cancer receiving RC. PATIENTS AND

METHODS:

We analysed data for 2570 patients from a Japanese nationwide cohort with bladder cancer treated with RC between January 2013 and December 2019 at 36 institutions. The non-urinary tract recurrence-free survival (NUTR-FS) and overall survival (OS) stratified by TUR or RC specimen histology were determined. We also elucidated the predictive factors for OS in patients with subtype/DD bladder cancer.

RESULTS:

At median follow-up of 36.9 months, 835 (32.4%) patients had NUTR, and 691 (26.9%) died. No statistically significant disparities in OS or NUTR-FS were observed when TUR specimens were classified as pure-urothelial carcinoma (UC), subtypes, DD, or non-UC. Among 2449 patients diagnosed with pure-UC or subtype/DD in their TUR specimens, there was discordance between the pathological diagnosis in TUR and RC specimens. Histological subtypes in RC specimens had a significant prognostic impact. When we focused on 345 patients with subtype/DD in TUR specimens, a multivariate Cox regression analysis identified pre-RC neutrophil-lymphocyte ratio and pathological stage as independent prognostic factors for OS (P = 0.016 and P = 0.001, respectively). The presence of sarcomatoid subtype in TUR specimens and lymphovascular invasion in RC specimens had a marginal effect (P = 0.069 and P = 0.056, respectively).

CONCLUSION:

This study demonstrated that the presence of subtype/DD in RC specimens but not in TUR specimens indicated a poor prognosis. In patients with subtype/DD in TUR specimens, pre-RC neutrophil-lymphocyte ratio and pathological stage were independent prognostic factors for OS.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Cistectomía Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: BJU Int Asunto de la revista: UROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Cistectomía Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: BJU Int Asunto de la revista: UROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón