Solution NMR Analysis of O-Glycopeptide-Antibody Interaction.
Methods Mol Biol
; 2763: 321-327, 2024.
Article
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| MEDLINE
| ID: mdl-38347421
ABSTRACT
O-Linked glycans potentially play a functional role in cellular recognition events. Recent structural analyses suggest that O-glycosylation can be a specific signal for a lectin receptor which recognizes both the O-glycan and the adjacent polypeptide region. Further, certain antibodies specifically bind to the O-glycosylated peptide. There is growing interest in the mechanism by which O-glycans on proteins are specifically recognized by lectins and antibodies. The recognition system may be common to many O-glycosylated proteins; however, there is limited 3D structural information on the dual recognition of glycan and protein. This chapter describes a solution NMR analysis of the interaction between MUC1 O-glycopeptide and anti-MUC1 antibody MY.1E12.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glicopéptidos
/
Mucina-1
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón