Bilateral exploration in primary hyperparathyroidism: Double adenoma distribution and biochemical patterns over two decades.
Am J Surg
; 233: 61-64, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38365553
ABSTRACT
BACKGROUND:
We investigated if anatomic patterns of abnormal parathyroid glands have ch anged for primary hyperparathyroidism (pHPT) as atypical biochemical presentation (normohormonal and normocalcemic) has increased.METHODS:
Retrospective review of patients with pHPT who underwent routine bilateral neck exploration.RESULTS:
2762 patients were included. The "late" cohort (2014-2020) exhibited lower preoperative calcium (10.8 vs 11.1 âmg/dL; P â= â0.001) and PTH levels (101 vs. 146 âpg/mL; P â= â0.001) compared to the "early" cohort (2000-2006). Patients with atypical biochemical profiles increased from 25.5% to 31.3% (P â< â0.001). The prevalence of single adenoma (SA) decreased (66.1% vs 58.9%, P â= â0.02) while the proportion of double adenoma (DA) increased (17.3% vs. 22.6%, P â< â0.01). Upper parathyroid adenoma(s) remained the most common finding for SA and DA in both time points.CONCLUSIONS:
Despite changes in patient characteristics, single upper adenoma and bilateral double upper adenomas remain the most common findings for patients with pHPT.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de las Paratiroides
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Adenoma
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Hiperparatiroidismo Primario
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Am J Surg
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos