Synthesis of <i>C</i>-Oligosaccharides via Ni-Catalyzed Reductive Hydroglycosylation.

Gulzar, Tayyab; Liu, Yan-Hua; Xia, Yu-Nong; Liu, Wei; Liu, Pengchao; Zhu, Dapeng; Xu, Peng; Yu, Biao

Synthesis of C-Oligosaccharides via Ni-Catalyzed Reductive Hydroglycosylation.

Gulzar, Tayyab; Liu, Yan-Hua; Xia, Yu-Nong; Liu, Wei; Liu, Pengchao; Zhu, Dapeng; Xu, Peng; Yu, Biao.

Afiliación

Gulzar T; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Liu YH; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Xia YN; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Liu W; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Liu P; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Zhu D; Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Xu P; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Yu B; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou 310024, China.

Org Lett ; 26(8): 1718-1722, 2024 Mar 01.

Article en En | MEDLINE | ID: mdl-38380896

ABSTRACT

ABSTRACT

C-Oligosaccharides are metabolically stable surrogates of native glycans containing O/N/S-glycosidic linkages and thus have therapeutic potential. Here we report a straightforward approach to the synthesis of vinyl C-linked oligosaccharides via the Ni-catalyzed reductive hydroglycosylation of alkynyl glycosides with glycosyl bromides.

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Org Lett / Org. lett / Organic letters Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China

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