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Intrauterine exposure to SARS-CoV-2 infection and early newborn brain development.
Andescavage, Nickie; Lu, Yuan-Chiao; Wu, Yao; Kapse, Kushal; Keller, Jennifer; Von Kohorn, Isabelle; Afifi, Ashraf; Vezina, Gilbert; Henderson, Deidtra; Wessel, David L; du Plessis, Adre J; Limperopoulos, Catherine.
Afiliación
  • Andescavage N; Developing Brain Institute, Children's National Hospital, 111 Michigan Ave. NW, Washington, DC 20010, United States.
  • Lu YC; Division of Neonatology, Children's National Hospital, 111 Michigavn Ave. NW, Washington, DC 20010, United States.
  • Wu Y; Department of Pediatrics, School of Medicine and Health Sciences, George Washington University, 2300 Eye St. NW Washington, DC 20052, United States.
  • Kapse K; Developing Brain Institute, Children's National Hospital, 111 Michigan Ave. NW, Washington, DC 20010, United States.
  • Keller J; Developing Brain Institute, Children's National Hospital, 111 Michigan Ave. NW, Washington, DC 20010, United States.
  • Von Kohorn I; Developing Brain Institute, Children's National Hospital, 111 Michigan Ave. NW, Washington, DC 20010, United States.
  • Afifi A; Department of Obstetrics and Gynecology, School of Medicine and Health Sciences, George Washington University, 2300 Eye Ste. NW, Washington, DC 20052, United States.
  • Vezina G; Department of Neonatology, Holy Cross Hospital, 1500 Forest Glen Rd. Silver Spring, MD 20910, United States.
  • Henderson D; Department of Hospital-Based Regional Neonatology at Woodbridge, Children's National Hospital, 111 Michigan Ave. NW, Washington, DC 20010, United States.
  • Wessel DL; Developing Brain Institute, Children's National Hospital, 111 Michigan Ave. NW, Washington, DC 20010, United States.
  • du Plessis AJ; Developing Brain Institute, Children's National Hospital, 111 Michigan Ave. NW, Washington, DC 20010, United States.
  • Limperopoulos C; Department of Pediatrics, School of Medicine and Health Sciences, George Washington University, 2300 Eye St. NW Washington, DC 20052, United States.
Cereb Cortex ; 34(2)2024 01 31.
Article en En | MEDLINE | ID: mdl-38385890
ABSTRACT
Epidemiologic studies suggest that prenatal exposures to certain viruses may influence early neurodevelopment, predisposing offspring to neuropsychiatric conditions later in life. The long-term effects of maternal COVID-19 infection in pregnancy on early brain development, however, remain largely unknown. We prospectively enrolled infants in an observational cohort study for a single-site study in the Washington, DC Metropolitan Area from June 2020 to November 2021 and compared these infants to pre-pandemic controls (studied March 2014-February 2020). The primary outcomes are measures of cortical morphometry (tissue-specific volumes), along with global and regional measures of local gyrification index, and sulcal depth. We studied 210 infants (55 infants of COVID-19 unexposed mothers, 47 infants of COVID-19-positive mothers, and 108 pre-pandemic healthy controls). We found increased cortical gray matter volume (182.45 ± 4.81 vs. 167.29 ± 2.92) and accelerated sulcal depth of the frontal lobe (5.01 ± 0.19 vs. 4.40 ± 0.13) in infants of COVID-19-positive mothers compared to controls. We found additional differences in infants of COVID-19 unexposed mothers, suggesting both maternal viral exposures, as well as non-viral stressors associated with the pandemic, may influence early development and warrant ongoing follow-up.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: COVID-19 Límite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: COVID-19 Límite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos