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Immune regulation and blood-brain barrier permeability in cerebral small vessel disease: study protocol of the INflammation and Small Vessel Disease (INSVD) study - a multicentre prospective cohort study.
Low, Audrey; van Winden, Sanne; Cai, Lupei; Kessels, Roy P C; Maas, Marnix C; Morris, Robin G; Nus, Meritxell; Tozer, Daniel J; Tuladhar, Anil; van der Kolk, Anja; Wolters, Rowan; Mallat, Ziad; Riksen, Niels P; Markus, Hugh; de Leeuw, Frank-Erik.
Afiliación
  • Low A; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK al927@medschl.cam.ac.uk.
  • van Winden S; Department of Neurology, Radboudumc, Nijmegen, The Netherlands.
  • Cai L; Radboud University Donders Institute for Brain Cognition and Behaviour, Nijmegen, The Netherlands.
  • Kessels RPC; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Maas MC; Radboud University Donders Institute for Brain Cognition and Behaviour, Nijmegen, The Netherlands.
  • Morris RG; Vincent Van Gogh Instituut, Venray, The Netherlands.
  • Nus M; Department of Radiology and Nuclear Medicine, Radboudumc, Nijmegen, The Netherlands.
  • Tozer DJ; Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
  • Tuladhar A; Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
  • van der Kolk A; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Section of Cardiorespiratory Medicine, Department of Medicine, University of Cambridge Medicine, Cambridge, UK.
  • Wolters R; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Mallat Z; Department of Neurology, Radboudumc, Nijmegen, The Netherlands.
  • Riksen NP; Radboud University Donders Institute for Brain Cognition and Behaviour, Nijmegen, The Netherlands.
  • Markus H; Department of Radiology and Nuclear Medicine, Radboudumc, Nijmegen, The Netherlands.
  • de Leeuw FE; Department of Neurology, Radboudumc, Nijmegen, The Netherlands.
BMJ Open ; 14(2): e084303, 2024 Feb 26.
Article en En | MEDLINE | ID: mdl-38413153
ABSTRACT

INTRODUCTION:

The INflammation and Small Vessel Disease (INSVD) study aims to investigate whether peripheral inflammation, immune (dys)regulation and blood-brain barrier (BBB) permeability relate to disease progression in cerebral small vessel disease (SVD). This research aims to pinpoint specific components of the immune response in SVD relating to disease progression. This could identify biomarkers of SVD progression, as well as potential therapeutic targets to inform the development and repurposing of drugs to reduce or prevent SVD, cognitive decline and vascular dementia. METHODS AND

ANALYSIS:

INSVD is a prospective observational multicentre cohort study in individuals with symptomatic SVD. This longitudinal study combines comprehensive immunophenotyping of the peripheral blood immune compartment with advanced neuroimaging markers of SVD and BBB permeability. The main SVD marker of interest is white matter microstructure as determined by diffusion tensor imaging, a valuable marker of disease progression owing to its sensitivity to early alterations to white matter integrity. The research is being conducted in two sites-in the UK (Cambridge) and the Netherlands (Nijmegen)-with each site recruiting 100 participants (total n=200). Participants undergo clinical and cognitive assessments, blood draws, and brain MRI at baseline and 2-year follow-up. ETHICS AND DISSEMINATION This study received ethical approval from the local ethics boards (UK East of England-Cambridge Central Research Ethics Committee (REC) ref 22/EE/00141, Integrated Research Application System (IRAS) ID 312 747. Netherlands Medical Research Ethics Committee (MREC) Oost-Nederland, ref 2022-13623, NL-number NL80258.091.22). Written informed consent was obtained from all subjects before the study. Any participant-derived benefits resulting from this research, such as new insights into disease mechanisms or possible novel therapies, will be disseminated to study participants, patient groups and members of the public. TRIAL REGISTRATION NUMBER NCT05746221.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Imagen de Difusión Tensora / Enfermedades de los Pequeños Vasos Cerebrales Límite: Humans Idioma: En Revista: BMJ Open Año: 2024 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Imagen de Difusión Tensora / Enfermedades de los Pequeños Vasos Cerebrales Límite: Humans Idioma: En Revista: BMJ Open Año: 2024 Tipo del documento: Article